TABLE 4.
Unadjusted and multivariable-adjusted RH (95% CI) for diabetes among interim birth groups by GDM status and stratified by baseline parity groups
| Interim birth groups stratified by baseline parity groups |
n | Unadjusted | Model 1 | Model 2 | Model 3 | Model 4 (fully adjusted) |
Model 4 + physical activity change(mediator) |
Model 4 + weight change (mediator) |
Model 4 + waist girth change (mediator) |
|---|---|---|---|---|---|---|---|---|---|
| Nulliparous at baseline | |||||||||
| 0 births (referent) | 737 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| ≥1 birth without GDM | 720 | 0.7 (0.5–1.1) | 0.7 (0.5–1.1) | 0.7 (0.5–1.1) | 0.9 (0.6–1.3) | 0.9 (0.6–1.4) | 0.8 (0.5–1.3) | 0.8 (0.5–1.3) | 0.8 (0.5–1.2) |
| ≥1 birth with GDM | 96 | 3.7 (2.2–6.4) | 3.1 (1.8–5.4) | 3.0 (1.8–5.2) | 3.5 (2.0–6.0) | 3.8 (2.2–6.6) | 3.7 (2.1–6.4) | 3.8 (2.2–6.6) | 3.4 (2.0–6.0) |
| Parous at baseline | |||||||||
| 0 or ≥1 birth without GDM | 778 | 1.4 (1.0–1.9) | 1.2 (0.9–1.8) | 1.2 (0.9–1.8) | 0.9 (0.6–1.3) | 0.8 (0.5–1.2) | 0.8 (0.5–1.1) | 0.8 (0.5–1.1) | 0.8 (0.5–1.1) |
| 0 or ≥1 birth with GDM | 77 | 4.8 (2.9–8.2) | 3.7 (2.2–6.3) | 3.5 (2.0–5.9) | 3.2 (1.9–5.5) | 2.9 (1.7–5.0) | 2.7 (1.5–4.7) | 2.7 (1.6–4.7) | 2.6 (1.5–4.5) |
Model 1 is adjusted for family history of diabetes; model 2 for family history of diabetes plus baseline FPG; model 3 for all of the above plus baseline BMI, age, and race; and model 4 (fully adjusted) for all of the above plus baseline covariates (education, smoking, and physical activity).