TABLE 2.
Immunosuppressiona
| Tacrolimus | |
| Preoperative | 0.15 mg/kg orally |
| Postoperative | 0.025–0.05 mg/kg intravenously, continuous infusion, until tolerating orally, then 0.15 mg/kg orally twice a day |
| Target levels (ng/ml whole blood IMX) | |
| First 2 weeks | 20–25 |
| 1 month | 15–20 |
| 3 months | 10–15 |
| Chronically | 5–12 |
| Steroids (intravenous methylprednisolone or po prednisone) | |
| Intraoperative | 1000 mg |
| POD 1–6 | 200 → 20 mg/day |
| 3–4 weeks | 15 mg/day, then 2.5 mg/d decrement to |
| 2–3 months | 10 mg/day, then |
| Every 4–6 weeks | 1.25–2.5 mg/day decrement, to 0 mg/day, if possible |
| Mycophenolate mofetil | |
| Preoperative | 1000 mg orally |
| Postoperative | 1000 mg orally twice a day |
a
IMX, POD, postoperative day.