TABLE 2.
Tacrolimus | |
Preoperative | 0.15 mg/kg orally |
Postoperative | 0.025–0.05 mg/kg intravenously, continuous infusion, until tolerating orally, then 0.15 mg/kg orally twice a day |
Target levels (ng/ml whole blood IMX) | |
First 2 weeks | 20–25 |
1 month | 15–20 |
3 months | 10–15 |
Chronically | 5–12 |
Steroids (intravenous methylprednisolone or po prednisone) | |
Intraoperative | 1000 mg |
POD 1–6 | 200 → 20 mg/day |
3–4 weeks | 15 mg/day, then 2.5 mg/d decrement to |
2–3 months | 10 mg/day, then |
Every 4–6 weeks | 1.25–2.5 mg/day decrement, to 0 mg/day, if possible |
Mycophenolate mofetil | |
Preoperative | 1000 mg orally |
Postoperative | 1000 mg orally twice a day |
IMX, POD, postoperative day.