TABLE 2.
| Mean | Treatment group |
Pre-LTxa | PostLTx days | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 7 | 14 | 27 | 28 | 60 | 90 | 180 | 270 | 360 | |||
| Renal function | |||||||||||
| BUN (mg/dl) | Double | 21 | 52 | 56 | 51 | 45 | 29 | 28 | 29 | 26 | 23 |
| Triple | 22 | 45 | 45 | 49 | 44 | 28 | 24 | 27 | 26 | 23 | |
| Creatinine (mg/dl) | Double | 1.26 | 1.77 | 2 | 2.1 | 2.1 | 1.41 | 1.37 | 1.37 | 1.47 | 1.39 |
| Triple | 1.32 | 1.55 | 1.6 | 1.8 | 1.6 | 1.44 | 1.31 | 1.38 | 1.46 | 1.42 | |
| Hematology | |||||||||||
| Anemia % (Hct<25%) | Double | 12 | 14 | 25 | 19 | 22 | 9 | 4 | 4 | 0 | 3 |
| Triple | 13 | 12 | 15 | 20 | 22 | 7 | 6 | 2 | 2 | 0 | |
| Leukopenia % (WBC<4.000/mm3 | Double | 24 | 0 | 6 | 0 | 4 | 17 | 15 | 22 | 14 | 22 |
| Triple | 31 | 4 | 3 | 9 | 9 | 20 | 27 | 20 | 22 | 20 | |
| Thrombocytopenia % (platelets<50.000/mn3 | Double | 24 | 20 | 12 | 3 | 2 | 2 | 4 | 2 | 0 | 3 |
| Triple | 25 | 25 | 5 | 4 | 6 | 3 | 3 | 2 | 2 | 8 | |
| Baseline immunosuppression | |||||||||||
| Tacrolimus dose (mg/day) | Double | 8.4 | 9.5 | 10.5 | 9.9 | 8.6 | 8.2 | 7.2 | 5.7 | 5.3 | |
| Triple | 9.2 | 10.8 | 9.6 | 9.2 | 8 | 8 | 6.9 | 6.5 | 5.3 | ||
| Tacrolimus level (ng/ml) | Double | 15.8 | 14.5 | 15.3 | 14.5 | 11.9 | 12.2 | 11.1 | 10.1 | 10.6 | |
| Triple | 15.1 | 14.2 | 13.9 | 14.2 | 11.8 | 11.6 | 11.5 | 10.6 | 10.7 | ||
| Prednisone (mg/day) | Double | 20 | 18.6 | 16.1 | 14.2 | 10 | 18.7 | 5.7 | 4.6 | 3.3 | |
| Triple | 20 | 18.3 | 15.6 | 13.2 | 9.1 | 7.2 | 5.3 | 3.6 | 2 | ||
a
Abbreviation used in table: LTx, liver transplantation.