Table 3.
Adenine nucleotides and purine catabolites of pre- and post-transplantation biopsies. Values indicate mean ± SEM. EC, Energy charge; ATP, adenosine triphosphate; ADP, adenosine diphosphate; AMP, adenosine monophosphate; ADE, adenosine; lNO, inosine; HX, hypoxanthine; X, xanthine; TAN, total adenine nucleotide; TPC, total purine catabolite; T, TAN + TPC; NAD +, nicotinamide adenine dinucleotide, oxidized form
| Control (μmol/g) | Pre-tx (μmol/g) |
Post-tx (μmol/g) |
|||
|---|---|---|---|---|---|
| Group A (n = 68) |
Group B (n = 4) |
Group A (n = 58) |
Group B (n = 3) |
||
| EC | 0.713 ± 0.0465 | 0.384 ± 0.0133* | 0.362 ± 0.0445* | 0.655 ± 0.00963 | 0.583 ± 0.0108 |
| ATP | 2.080 ± 0.298 | 0.853 ± 0.0517* | 0.640 ± 0.123* | 1.77 ± 0.0929 | 0.712 ± 0.172** |
| ADP | 1.17 ± 0.0628 | 1.39 ± 0.0814 | 1.12 ± 0.125 | 1.45 ± 0.0524 | 0.726 ± 0.127*, ** |
| AMP | 0.445 ± 0.115 | 1.93 ± 0.190* | 1.53 ± 0.204* | 0.549 ± 0.0302 | 0.398 ± 0.0829 |
| ADE | 0.0358 ± 0.00899 | 0.423 ± 0.0420* | 0.348 ± 0.0146* | 0.0916 ± 0.00667* | 0.0593 ± 0.00145 |
| INO | 0.121 ± 0.0198 | 1.18 ± 0.0708* | 1.20 ± 0.0774* | 0.314 ± 0.0273* | 0.161 ± 0.0350 |
| HX | 0.118 ± 0.0244 | 1.14 ± 0.135* | 1.21 ± 0.210* | 0.473 ± 0.0668* | 0.161 ± 0.0913 |
| X | 0.0087 ± 0.0052 | 0.216 ± 0.0296* | 0.285 ± 0.0511* | 0.0538 ± 0.01 09 | 0.0713 ± 0.0270 |
| TAN | 3.69 ± 0.223 | 4.17 ± 0.285 | 3.30 ± 0.174 | 3.77 ± 0.138 | 1.84 ± 0.379*, ** |
| TPC | 0.284 ± 0.0336 | 2.95 ± 0.232* | 3.04 ± 0.271* | 0.932 ± 0.0905* | 0.452 ± 0.114 |
| T | 3.97 ± 0.233 | 7.12 ± 0.49* | 6.34 ± 0.309* | 4.704 ± 0.167 | 2.29 ± 0.426*, ** |
| NAD + | 0.632 ± 0.0440 | 0.671 ± 0.364 | 0.582 ± 0.0900 | 0.821 ± 0.0382 | 0.406 ± 0.0609* |
*
P < 0.05 vs control
**
P < 0.05 vs group A of the same biopsy