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Mean ceftobiprole concentration in plasma (circles), free plasma (dashed line), skeletal muscle (squares), and s.c. adipose tissue (triangles) over 12 h. Reprinted with permission from Barbour A, Schmidt S, Sabarinath SN, et al. Soft-tissue penetration of ceftobiprole in healthy volunteers determined by in vivo microdialysis. Antimicrob Agents Chemother. 2009;53:2773–2776.54 Copyright © 2009 American Society for Microbiology.
