TABLE II.
Effect of Cyclosporin and FK 506 on Rat Liver Regeneration (Mean, SE)
| Group |
3H-thymidine incorporation (× 103 cpm/mg DNA) |
Proportion of hepatocytes in mitosis (%) |
|---|---|---|
| 1 | 3·3 (0·4) | 1·6 (0·1) |
| 2 | 3·2 (0·3) | 1·7 (0·1) |
| 3 | 4·9 (0·5) | 6·8 (0·6)¶ |
| 4 | 10·5 (0·8)* | 9·5 (0·5)∥ |
| 5 | 12·5 (1·3) | ‥ |
| 6 | 32·4 (8·2)† | ‥ |
| 7 | 138·1 (13·1) | 31·0 (2·0) |
| 8 | 130·0 (9·2) | 29·0 (2·8) |
| 9 | 179·0 (14·0)‡ | 44·0 (2·1)‡ |
| 10 | 242·0 (28·0)§ | 59·0 (3·0)§ |
Student’s t test:
*
p < 0·005 vs groups 1, 2, and 3.
†
p < 0·001 vs group 5.
‡
p < 0·05 vs group 7.
§
p < 0·001 vs group 8.
¶
p < 0·01 vs groups 1 and 2.
∥
p < 0·05 vs groups 1 and 2.