TABLE 3.

Gender difference of hepatic BA and BA synthetic enzymes in mice fed various BA-supplemented diets

	Hepatic BA		BA-synthetic Enzymes
	M > F	M < F	M > F	M < F
Control	αMCA, ωMCA, CDCA, LCA,7-oxoDCA, 7-oxoLCA, 12-oxoLCA		Cyp8b1, Cyp7b1
1% CA	αMCA, βMCA, ωMCA, CA, MDCA, UDCA, HDCA, isoDCA, CDCA, DCA, 7-oxoDCA, 12-oxoCDCA, 12-oxoLCA	TMDCA	Cyp7b1	Cyp27a1
0.3% DCA	TDCA, GDCA, DCA, GCA, isoDCA, 7-oxoDCA, 12-oxoLCA	TUDCA, UDCA	Cyp7b1	Cyp7a1, Cyp27a1
0.3% CDCA	CDCA, DCA, LCA, 7-oxoDCA, 6-oxoLCA, 7-oxoLCA, 12-oxoLCA		Cyp8b1, Cyp7b1
0.3% LCA	7-oxoDCA, 6-oxoLCA, 12-oxoLCA		Cyp7b1
3% UDCA	7-oxoDCA		Cyp7b1	Cyp8b1
2% Resin	CA, 7-oxoDCA	TαMCA, TβMCA, TωMCA, THCA, TCDCA, TMDCA, TUDCA, THDCA, TLCA, HDCA, LCA	Cyp7b1	Cyp7a1, Cyp27a1

BA, bile acid; CA, cholic acid; Cyp, cytochrome P450; CDCA, chenodeoxycholic acid; DCA, deoxycholic acid; F, female; GCA, glycocholic acid; GDCA, glycodeoxycholic acid; HDCA, hyodeoxycholic acid; LCA, lithocholic acid; M, male; αMCA, α-muricholic acid; βMCA, β-muricholic acid; ωMCA, ω-muricholic acid; MDCA, murideoxycholic acid; 12-oxoCDCA, 3α,7α-dihydroxy-12-oxo-5β–cholan-24-oic acid; 7-oxoDCA, 3α,12α-dihydroxy-7-oxo-5β–cholan-24-oic acid; 7-oxoLCA, 3α-hydroxy-7-oxo-5β–cholan-24-oic acid; 12-oxoLCA, 3α-hydroxy-12-oxo-5β–cholan-24-oic acid; TCDCA, taurochenodeoxycholic acid; TDCA, taurodeoxycholic acid; THCA, taurohyocholic acid; THDCA, taurohyodeoxycholic acid; TLCA, taurolithocholic acid; TαMCA, tauro-α-muricholic acid; TβMCA, tauro-β-muricholic acid; TωMCA, tauro-ω-muricholic acid; TMDCA, tauromurideoxycholic acid; TUDCA, tauroursodeoxycholic acid; UDCA, ursodeoxycholic acid.