TABLE 1.
Anthropometric and biochemical parameters of controls and patients with CAD
| Control (n = 1123) | CAD (n = 807) | |
|---|---|---|
| Male/Female, (%) | 78.4/21.6 | 81.5/18.5 |
| Age (yr) | 56.1 ± 0.23 | 56.9 ± 0.34 |
| BMI (kg/m2) | 24.1 ± 0.07 | 25.1 ± 0.10 |
| Blood pressure (mm Hg) | ||
| Systolic | 124.1 ± 0.46 | 127.2 ± 0.60 |
| Diastolic | 78.4 ± 0.32 | 77.3 ± 0.36 |
| Fasting glucose (mg/dl)a | 86.6 ± 0.24 | 88.8 ± 0.44* |
| Triglycerides (mg/dl)a | 128.9 ± 2.22 | 147.3 ± 2.80*** |
| ApoA5 (ng/ml)a | 225.1 ± 3.55 | 197.4 ± 5.02*** |
| Total-cholesterol (mg/dl) | 195.5 ± 0.99 | 166.2 ± 1.38*** |
| LDL-cholesterol (mg/dl) | 117.9 ± 0.91 | 90.7 ± 1.25*** |
| HDL-cholesterol (mg/dl)a | 51.7 ± 0.42 | 45.5 ± 0.39*** |
| LDL particle size (nm) | 23.76 ± 0.02 | 23.47 ± 0.03*** |
| TNF-α (pg/ml)a | 5.38 ± 0.10 | 5.65 ± 0.43 |
| hs-CRP (mg/dl)a | 1.14 ± 0.06 | 2.08 ± 0.15*** |
| Malondialdehyde (nmol/ml)a | 9.18 ± 0.09 | 10.5 ± 0.17*** |
| 8-epi-PGF2α (pg/mg creatinine)a | 1296.4 ± 18.2 | 1417.5 ± 27.0*** |
| Ox-LDL (μ/l)a | 63.5 ± 0.75 | 59.5 ± 0.89*** |
| FA composition (%) in serum PL | ||
| Total polyunsaturated ω-6 FA | 20.6 ± 0.19 | 20.6 ± 0.20 |
| 18:2(ω-6) | 12.9 ± 0.13 | 12.1 ± 0.13*** |
| 18:3(ω-6)a | 0.27 ± 0.01 | 0.24 ± 0.01 |
| 20:2(ω-6)a | 0.63 ± 0.05 | 0.36 ± 0.01*** |
| 20:3(ω-6) | 1.61 ± 0.03 | 1.86 ± 0.03*** |
| 20:4(ω-6) | 4.84 ± 0.07 | 5.72 ± 0.10*** |
| Total polyunsaturated ω-3 FA | 5.39 ± 0.09 | 5.51 ± 0.12 |
| 18:3(ω-3)a | 0.16 ± 0.00 | 0.17 ± 0.01 |
| 20:3(ω-3)a | 0.09 ± 0.01 | 0.08 ± 0.00* |
| 20:5(ω-3)a | 1.28 ± 0.03 | 1.44 ± 0.05 |
| 22:5(ω-3)a | 0.60 ± 0.01 | 0.60 ± 0.01 |
| 22:6(ω-3)a | 3.25 ± 0.06 | 3.21 ± 0.07 |
| 20:4(ω-6)/20:3(ω-6) | 3.17 ± 0.04 | 3.21 ± 0.06* |
| AA/LA | 0.38 ± 0.01 | 0.48 ± 0.01 |
| APOA5 -1131T>C, n(%) | ||
| TT | 566 (50.4) | 363 (45.0) |
| TC | 455 (40.5) | 367 (45.5) |
| CC | 102 (9.1) | 77 (9.5) |
| FEN1 10154 G>T, n(%) | ||
| GG | 516 (45.9) | 399 (49.4) |
| GT | 494 (44.0) | 330 (40.9) |
| TT | 113 (10.1) | 78 (9.7) |
Mean ± SE. P-values were tested with a paired t-test. *P < 0.05, **P < 0.01, ***P < 0.001; adjusted for sex, age, BMI, cigarette smoking, alcohol consumption, and systolic and diastolic BP.
a
Logarithmic transformation.