TABLE 3.
Associations of the APOA5 -1131T>C genotypes with plasma apoA5, lipid profiles, and ω6 PUFA in serum phospholipids
| Control (n = 1123) |
CAD (n = 807) |
|||
|---|---|---|---|---|
| APOA5 TT(n = 566) | APOA5 C allele (n = 557) | APOA5 TT(n = 363) | APOA5 C allele (n = 444) | |
| ApoA5 (ng/ml)a | 238.2 ± 5.21 | 213.7 ± 4.78*** | 213.1 ± 7.70 | 185.0 ± 6.50*** |
| Triglyceride (mg/dl)a | 118.3 ± 2.56 | 139.6 ± 3.58*** | 136.8 ± 3.51 | 156.0 ± 4.17*** |
| HDL-cholesterol (mg/dl)a | 52.8 ± 0.59 | 50.7 ± 0.59** | 46.2 ± 0.58 | 44.9 ± 0.52* |
| LDL particle size (nm) | 23.8 ± 0.03 | 23.7 ± 0.03*** | 23.6 ± 0.04 | 23.4 ± 0.04*** |
| 18:2(ω6) | 12.9 ± 0.17 | 12.8 ± 0.18 | 12.0 ± 0.18 | 12.3 ± 0.19 |
| 20:3(ω6) | 1.69 ± 0.04 | 1.53 ± 0.03** | 1.89 ± 0.05 | 1.84 ± 0.04 |
| 20:4(ω6) | 4.95 ± 0.10 | 4.74 ± 0.10 | 5.65 ± 0.15 | 5.77 ± 0.13 |
| 20:4(ω6)/20:3(ω6) | 3.11 ± 0.06 | 3.23 ± 0.06 | 3.11 ± 0.08 | 3.29 ± 0.08 |
| AA/LA | 0.39 ± 0.01 | 0.37 ± 0.01 | 0.48 ± 0.01 | 0.49 ± 0.01 |
Mean ± SE. P-values were tested with a paired t-test, *P < 0.05, **P < 0.01, ***P < 0.001; adjusted for sex, age, BMI, cigarette smoking, alcohol consumption, and systolic and diastolic BP.
a
Logarithmic transformation.