TABLE 4.
Associations of the FEN1 10154 G>T genotypes with serum lipids, lipid peroxides, and ω6 PUFA in serum phospholipids
| Control (n = 1123) |
CAD (n = 807) |
|||
|---|---|---|---|---|
| FEN1 10154GG (n = 516) | FEN1 10154T allele (n = 607) | FEN1 10154 GG n = 399) | FEN1 10154T allele (n = 408) | |
| Total-cholesterol (mg/dl) | 197.6 ± 1.48 | 193.6 ± 1.34* | 164.4 ± 1.91 | 168.0 ± 1.99 |
| LDL particle size (nm) | 23.7 ± 0.03 | 23.8 ± 0.03 | 23.4 ± 0.03 | 23.5 ± 0.04** |
| Malondialdehyde (nmol/ml)a | 9.41 ± 0.15 | 8.98 ± 0.11* | 10.6 ± 0.27 | 10.4 ± 0.21 |
| 8-epi-PGF2α (pg/mg creatinine)a | 1316.4 ± 28.3 | 1279.2 ± 23.6 | 1458.7 ± 41.2 | 1377.9 ± 35.0 |
| Ox-LDL (μ/L)a | 65.0 ± 1.13 | 62.2 ± 1.01* | 58.2 ± 1.17 | 60.7 ± 1.33 |
| 18:2(ω6) | 12.4 ± 0.18 | 13.2 ± 0.17** | 11.6 ± 0.18 | 12.7 ± 0.19*** |
| 20:3(ω6) | 1.67 ± 0.04 | 1.56 ± 0.03* | 1.82 ± 0.04 | 1.91 ± 0.05 |
| 20:4(ω6) | 5.36 ± 0.11 | 4.46 ± 0.09*** | 6.17 ± 0.15 | 5.22 ± 0.12*** |
| 20:4(ω6)/20:3(ω6) | 3.33 ± 0.06 | 3.05 ± 0.06*** | 3.52 ± 0.08 | 2.87 ± 0.07*** |
| AA/LA | 0.43 ± 0.01 | 0.34 ± 0.01*** | 0.54 ± 0.01 | 0.42 ± 0.01*** |
Mean ± SE. P-values were tested with a paired t-test, *P < 0.05, **P < 0.01, ***P < 0.001 adjusted for sex, age, BMI, cigarette smoking, alcohol consumption, and systolic and diastolic BP.
a
Logarithmic transformation.