Fig. 1.

A: Percentage of atherosclerotic lesion area as measured by Oil-Red-O staining on different levels in the aorta in apolipoprotein E knockout (apoE KO) and double knockout (DKO) mice. The mice were fed a cholesterol diet for 5 months. Serial sections of 0.1 mm were analyzed starting 0.1 mm distal to the aortic valve. * Statistically significant difference from the corresponding serial section in apoE KO mice, P < 0.05. B: Atherosclerotic lesions in the same section of the proximal aorta from an apoE KO mouse (left) and a DKO mouse (right). Lesions were stained with Oil-Red-O and hematoxylin. Data are presented as mean ± SEM.