TABLE 2.
Levels of cholesterol, triglycerides, and phospholipids in serum
| Serum Lipids (mmol/l) | Total Particles |
ApoB Particles |
ApoA-I Particles |
||||
|---|---|---|---|---|---|---|---|
| ApoE KO | DKO | ApoE KO | DKO | Apo E KO | DKO | ||
| Chow diet 2 weeks | TC | 12.7 ± 1.9 | 5.5 ± 0.9 | 11.2 ± 1.9 | 4.6 ± 0.7 | 1.5 ± 0.1 | 0.9 ± 0.2* |
| FC | 5.6 ± 0.6 | 3.5 ± 1.1 | 4.8 ± 0.5 | 3.1 ± 0.2 | 0.8 ± 0.2 | 0.4 ± 0.1 | |
| CE | 7.3 ± 0.4 | 3.0 ± 0.3 | 6.5 ± 0.5 | 2.4 ± 0.3 | 0.7 ± 0.2 | 0.6 ± 0.0 | |
| TG | 1.9 ± 0.6 | 1.2 ± 0.2 | 1.6 ± 0.5 | 1.1 ± 0.3 | 0.3 ± 0.2 | 0.1 ± 0.5 | |
| PL | 20.8 ± 1.3 | 18.4 ± 3.6 | 12.4 ± 0.7 | 10.9 ± 2.3 | 8.4 ± 0.7 | 7.5 ± 1.3 | |
| Cholesterol diet2 weeks | TC | 22.4 ± 3.0 | 14.7 ± 2.7* | 21.7 ± 3.1 | 13.5 ± 2.7* | 0.6 ± 0.3 | 1.3 ± 0.2* |
| FC | 7.1 ± 0.5 | 5.5 ± 0.4 | 6.9 ± 0.5 | 5.1 ± 0.4 | 0.2 ± 0.1 | 0.4 ± 0.0 | |
| CE | 15.3 ± 0.9 | 9.2 ± 1.0* | 14.8 ± 1.0 | 8.4 ± 1.0* | 0.5 ± 0.1 | 0.9 ± 0.1 | |
| TG | 0.6 ± 0.1 | 1.1 ± 0.0 | 0.5 ± 0.1 | 0.9 ± 0.0 | 0.1 ± 0.0 | 0.1 ± 0.0 | |
| PL | 21.4 ± 2.0 | 17.0 ± 1.0 | 17.0 ± 1.6 | 11.5 ± 0.7 | 4.4 ± 0.7 | 5.6 ± 0.4 | |
| Cholesterol diet5 months | TC | 26.8 ± 4.4 | 13.5 ± 3.2* | 25.9 ± 4.3 | 12.4 ± 3.2* | 0.9 ± 0.2 | 1.2 ± 0.1 |
| FC | 8.7 ± 0.6 | 5.3 ± 0.5* | 8.3 ± 0.5 | 4.9 ± 0.4* | 0.3 ± 0.1 | 0.4 ± 0.1 | |
| CE | 18.2 ± 1.7 | 8.2 ± 1.5* | 17.5 ± 1.9 | 7.4 ± 1.4* | 0.6 ± 0.1 | 0.8 ± 0.0 | |
| TG | 1.0 ± 0.2 | 1.1 ± 0.3 | 1.0 ± 0.2 | 1.0 ± 0.3 | 0.1 ± 0.0 | 0.1 ± 0.1 | |
| PL | 22.1 ± 1.4 | 16.8 ± 1.1 | 18.0 ± 1.1 | 12.1 ± 0.6 | 4.0 ± 0.3 | 4.8 ± 1.1 | |
Serum concentration of lipids. TC, total cholesterol; FC, free cholesterol; CE, cholesteryl ester; TG, triglyceride; PL, phospholipid in mmol/l of apoE KO and DKO animals fed a chow diet for 2 weeks or a cholesterol diet for 2 weeks or 5 months. The results are expressed as mean ± SEM (n = 4–5). * Statistically significant difference from apoE KO with the same diet, P < 0.05.