TABLE 3.
Bile acid composition of gallbladder bile
| Bile Acid Composition(% of Total Bile Acids) | DCA | CDCA+ α-Muricholic Acid | CA | UDCA | β-Muricholic Acid | |
|---|---|---|---|---|---|---|
| Chow diet | ApoE KO | <1 | 5.3 ± 1.7 | 52.0 ± 3.8 | <1 | 42.5 ± 4.0 |
| 2 weeks | DKO | <1 | 24.8 ± 1.9* | <1* | 3.5 ± 2.0* | 71.7 ± 3.5* |
| Cholesterol diet | ApoE KO | 1.6 ± 0.6 | 8.8 ± 0.4 | 51.2 ± 1.4 | 1.0 ± 0.6 | 37.4 ± 1.8 |
| 5 months | DKO | <1 | 36.9 ± 2.9* | <1* | 8.1 ± 0.7* | 47.8 ± 2.5 |
| Chow diet | ApoE KO | 1.0 ± 0.6 | 2.2 ± 1.0 | 64.3 ± 1.1 | <1 | 32.8 ± 1.5 |
| 6 days | DKO | <1 | 25.6 ± 0.8++ | 2.8 ± 2.8++ | 9.1 ± 0.8++ | 62.6 ± 2.1++ |
| Chow diet | DKO | <1 | 10.5 ± 6.2 | <1++ | 4.8 ± 2.8++ | 84.4 ± 9.1++ |
| 6 days + GW4064 | ||||||
| Chow diet | DKO | 3.6 ± 1.8 | 3.4 ± 1.4 | 72.9 ± 9.4 | 1.7 ± 1.3 | 18.4 ± 8.5 |
| 6 days + 0.2% CA |
The results are expressed as mean ± SEM (n = 3–5). Values represent percent (%) of total gallbladder bile acids. Before euthanization, the mice were fasted for 4 h. CDCA, chenodeoxycholic acid; UDCA, ursodeoxycholic acid; DCA, deoxycholic acid. * Statistically significant difference from apoE KO with the same diet. + Statistically significant difference from apoE KO chow diet for 6 days, P < 0.05.