Fig. 1.
ASO-mediated knockdown of CGI-58 prevents HFD-induced obesity. A: CGI-58 mRNA levels in the epididymal adipose tissue of mice treated with control ASO or CGI-58 ASO (CGI-58β). B: Western blot analysis of epididymal adipose tissue in chow-fed mice (exposure time: 15 s). C: Body weight in ad libitum chow-fed or HFD-fed mice (n = 9–10). * P < 0.01 (vs. saline within each time point). D: Gross appearance of HFD-fed mice and their epididymal fat pads, and the total epididymal fat pad weight (g) and the total epididymal fat pad weight expressed as % of body weight (BW) in both chow-fed and HFD-fed mice (n = 9–10). * P < 0.01 (vs. saline or control ASO within each diet).