TABLE 3.
Description of the APOB SNPs evaluated
| SNP | dbSNP IDa | Location | Minor Allele | Minor Allele Frequency | HWE Pb | Justification |
|---|---|---|---|---|---|---|
| −516 C→T | rs934197 | promoter | T | 0.334 | 0.2575 | (20–24) |
| Val591Ala | rs679899c | exon 14 | A | 0.463 | 0.0071 | (19) |
| XbaI | rs693 | exon 26 | G | 0.489 | 0.2708 | (20–23) |
| Pro2739Leu | rs676210 | exon 26 | T | 0.217 | 0.5386 | (19, 20–23, HapMapd) |
| EcoRI (Glu4514Lys) | rs1042031 | exon 29 | T | 0.173 | 0.7080 | (19) |
APOB, apolipoprotein B gene; HWE, Hardy-Weinberg equilibrium; SNP, single nucleotide polymorphism.
a
SNP ID in the database dbSNP (www.ncbi.nlm.nih.gov/SNP).
b
Hardy-Weinberg equilibrium test.
c
This SNP was excluded from further analysis.
d
HapMap SNP, early phase I.