TABLE 5.
Triglyceride response to fenofibrate by genotype adjusted for pretreatment triglycerides and other covariates
| Pre-Fenofibrate |
Post-Fenofibrate |
Change in Triglyceride (%) |
Change in Triglyceride (mg/dl) |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| SNP | Genotype | Number (%) | Geometric Mean(95% CI) | Pa | Geometric Mean(95% CI) | Pa | % Change(95% CI) | Pa | Absolute Change(95% CI) | Pa |
| rs934197 | CC | 413 (43.1) | 113.3 (111.3–115.3) | 0.8320 | 81.3 (79.3–83.4) | 0.9659 | −25.8 (-21.7 to -30.0) | 0.7088 | 31.8 (29.7–33.9) | 0.7431 |
| CT | 440 (45.9) | 114.2 (112.2–116.2) | 81.0 (79.0–83.0) | −27.0 (-22.9 to -31.1) | 30.5 (28.4–32.5) | |||||
| TT | 105 (11.0) | 112.7 (110.7–114.7) | 81.9 (79.8–83.9) | −25.3 (-19.6 to -31.0) | 30.9 (28.7–33.0) | |||||
| rs693 | AA | 252 (26.3) | 110.7 (108.7–112.7) | 0.1524 | 81.0 (79.0–83.0) | 0.9531 | −23.7 (-19.3 to -28.2) | 0.0847 | 30.4 (28.3–32.6) | 0.8263 |
| AG | 486 (50.7) | 114.5 (112.5–116.5) | 81.1 (79.0–83.1) | −27.9 (-23.8 to -32.0) | 31.6 (29.5–33.7) | |||||
| GG | 220 (23.0) | 115.2 (113.2 – 117.2) | 81.8 (79.8–83.8) | −26.3 (-21.7 to -30.9) | 30.7 (28.6–32.9) | |||||
| rs676210 | CC | 593 (61.9) | 113.2 (111.2 – 115.2) | 0.7946 | 82.4 (80.4–84.4) | 0.0467 | −24.7 (-20.8 to -28.5) | 0.0053 | 29.2 (27.1–31.2) | <0.0001 |
| CT | 319 (33.3) | 114.3 (112.3–116.3) | 81.0 (78.9–83.0) | −28.3 (-23.9 to -32.6) | 33.0 (30.9–35.1) | |||||
| TT | 46 (4.8) | 115.3 (113.3–117.4) | 71.2 (69.1–73.3) | −34.5 (-27.1 to -41.8) | 43.3 (41.2–45.5) | |||||
| rs1042031 | CC | 654 (68.3) | 113.4 (111.4–115.4) | 0.8897 | 80.8 (78.8–82.8) | 0.6920 | −26.8 (-22.9 to -30.8) | 0.6716 | 32.5 (30.4–34.6) | 0.1375 |
| CT | 277 (28.9) | 114.3 (112.3–116.3) | 82.7 (80.6–84.7) | −25.4 (-20.9 to -29.8) | 29.5 (27.4–31.6) | |||||
| TT | 27 (2.8) | 112.5 (110.4–114.5) | 78.8 (76.7–81.0) | −25.2 (-14.9 to -35.5) | 24.3 (21.9–26.7) | |||||
All values are adjusted for sex, field center, smoking status, diabetes status, age, waist circumference, baseline triglyceride, and family relatedness with the only significant covariate being baseline triglyceride (P < 0.0001).
a
Additive model.