TABLE 3.
PON1 activities and 8-epiPGF2a levels in the study population
| Control | β-TI | β-TM | |
|---|---|---|---|
| PON1 activity toward paraoxon (U/l) | 77.4 ± 35.1 | 37.8 ± 29.1a | 51.7 ± 28.7a |
| PON1 activity toward phenylacetate (U/ml) | 66.6 ± 7.3 | 39.4 ± 3.6a | 54.1 ± 8.7a |
| Serum 8-epiPGF2a (pg/ml) | 75.2 ± 27.3 | 98.1 ± 30.2a | 125.0 ± 35.8bc |
| Urine 8-epiPGF2a (ng/mg creatinine) | 0.48 ± 0.16 | 0.65 ± 0.22a | 0.80 ± 0.29bc |
Data represent the mean ± SD values. 8-epiPGF2a, 8-isoprostanes; β-TI, β-thalassemia intermedia; β-TM, β-thalassemia major PON1, paraoxonase 1.
a
P < 0.01 compared with control values.
b
P < 0.001 compared with control values.
c
P < 0.001 compared with β-TI values.