TABLE 1.
Association of the PCSK9 missense variant R46L with early-onset MI
| Minor Allele Frequency (%) |
||||||
|---|---|---|---|---|---|---|
| Study | N. Cases | N. Controls | Cases | Controls | OR (95% CI) | P |
| ATVB cases vs. ATVB ctrl | 1,872 | 1,865 | 1.04 | 1.42 | 0.75 (0.49-1.13) | 0.170 |
| Adjusted Values: | 0.78 (0.49-1.25) | 0.310 | ||||
| ATVB cases vs. Suppl-ctrl | 1,872 | 996 | 1.04 | 1.81 | 0.57 (0.36-0.90) | 0.019 |
| ATVB cases vs. ATVB ctrl+Suppl-ctrl | 1,872 | 2,861 | 1.04 | 1.55 | 0.67 (0.46-0.97) | 0.036 |
ATVB ctrl = controls collected in the frame of the ATVB study (20) on premature MI (mean age 39.6 ± 4.9); Suppl-ctrl = supplementary control group (mean age 53.9 ± 11.5). Significant results are in bold; adjustment took into account hypertension, smoking, diabetes, hypercholesterolemia, and BMI.