TABLE 3.
Association of SNPs located in the PCSK9 locus with early-onset MI, and LDL and total cholesterol levels
| Position on chr 1 (bp) | Minor Allele | Minor Allele Frequency (%) |
MI |
LDL Cholesterol |
Total Cholesterol |
|||||
|---|---|---|---|---|---|---|---|---|---|---|
| SNP | Cases | Controls | P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | ||
| rs2479394 | 55,258,652 | G | 31.1 | 30.4 | 0.518 | 1.04 (0.93–1.16) | 0.222 | 1.07 (0.96–1.19) | 0.862 | 1.01 (0.92–1.11) |
| rs2479393 | 55,260,957 | A | 30.0 | 28.9 | 0.362 | 1.05 (0.94–1.18) | 0.154 | 1.08 (0.97–1.2) | 0.721 | 1.02 (0.92–1.12) |
| rs2479417 | 55,268,332 | T | 38.0 | 36.7 | 0.227 | 1.07 (0.96–1.19) | 0.345 | 1.05 (0.95–1.16) | 0.488 | 1.03 (0.94–1.13) |
| rs2495497 | 55,268,583 | T | 13.6 | 12.8 | 0.646 | 1.04 (0.89–1.20) | 0.332 | 1.07 (0.93–1.24) | 0.325 | 1.07 (0.94–1.21) |
| rs11206510 | 55,268,627 | C | 18.9 | 20.6 | 0.144 | 0.91 (0.80–1.03) | 1.89E-03 | 0.82 (0.73–0.93) | 8.12E-05 | 0.80 (0.72–0.89) |
| rs2094470 | 55,269,890 | C | 6.5 | 5.9 | 0.182 | 1.15 (0.93–1.42) | 0.680 | 0.96 (0.79–1.17) | 0.603 | 1.05 (0.87–1.26) |
| rs7523242 | 55,271,537 | T | 22.4 | 21.0 | 0.384 | 1.06 (0.93–1.19) | 0.305 | 1.06 (0.94–1.20) | 0.256 | 1.06 (0.96–1.19) |
| rs2495488 | 55,272,794 | T | 5.6 | 5.5 | 0.653 | 1.05 (0.84–1.31) | 0.908 | 0.99 (0.80–1.22) | 0.694 | 1.04 (0.86–1.26) |
| rs2182833 | 55,273,017 | G | 22.8 | 21.7 | 0.457 | 1.05 (0.93–1.18) | 0.465 | 1.04 (0.93–1.18) | 0.310 | 1.06 (0.95–1.18) |
| rs10788994 | 55,273,564 | T | 22.8 | 21.5 | 0.401 | 1.05 (0.93–1.19) | 0.334 | 1.06 (0.94–1.19) | 0.225 | 1.07 (0.96–1.19) |
| rs2149041 | 55,274,725 | G | 22.3 | 21.0 | 0.406 | 1.06 (0.93–1.20) | 0.205 | 1.08 (0.96–1.22) | 0.192 | 1.08 (0.96–1.20) |
| rs2479409 | 55,277,238 | G | 34.2 | 33.3 | 0.442 | 1.04 (0.94–1.16) | 0.133 | 1.08 (0.98–1.20) | 0.025 | 1.11 (1.01–1.22) |
| rs10888897 | 55,277,985 | T | 42.0 | 43.5 | 0.256 | 0.94 (0.85–1.04) | 0.974 | 1.00 (0.91–1.11) | 0.954 | 1.00 (0.92–1.10) |
| rs2479412 | 55,285,649 | G | 4.8 | 4.7 | 0.903 | 0.99 (0.78–1.25) | 0.404 | 1.10 (0.88–1.37) | 0.155 | 1.16 (0.94–1.43) |
| rs2495477 | 55,286,661 | G | 39.4 | 42.2 | 0.105 | 0.92 (0.83–1.02) | 0.446 | 0.96 (0.87–1.07) | 0.121 | 0.93 (0.85–1.02) |
| rs2479413 | 55,291,055 | T | 31.8 | 33.8 | 0.180 | 0.93 (0.83–1.03) | 0.759 | 0.98 (0.88–1.09) | 0.366 | 0.96 (0.87–1.05) |
| rs7552841 | 55,291,270 | T | 40.2 | 39.9 | 0.792 | 0.99 (0.89–1.09) | 0.971 | 1.00 (0.90–1.11) | 0.456 | 1.04 (0.94–1.13) |
| rs693668 | 55,291,340 | G | 35.6 | 37.8 | 0.273 | 0.94 (0.85–1.05) | 0.404 | 0.96 (0.86–1.06) | 0.203 | 0.94 (0.86–1.03) |
| rs568052 | 55,293,697 | G | 29.2 | 30.0 | 0.569 | 0.97 (0.86–1.08) | 0.377 | 0.95 (0.85–1.06) | 0.174 | 0.93 (0.84–1.03) |
| rs631220 | 55,297,430 | A | 15.8 | 16.9 | 0.397 | 0.94 (0.82–1.08) | 0.399 | 0.94 (0.82–1.08) | 0.158 | 0.91 (0.81–1.04) |
| rs505151 | 55,300,067 | G | 3.8 | 3.2 | 0.390 | 1.13 (0.85–1.50) | 0.166 | 1.20 (0.93–1.55) | 0.098 | 1.22 (0.96–1.54) |
| rs13312 | 55,301,775 | G | 17.7 | 19.1 | 0.403 | 0.95 (0.83–1.08) | 0.721 | 0.98 (0.86–1.11) | 0.350 | 0.95 (0.84–1.06) |
| rs593398 | 55,305,330 | C | 3.6 | 3.4 | 0.676 | 1.06 (0.81–1.39) | 0.182 | 1.20 (0.92–1.58) | 0.474 | 1.09 (0.86–1.40) |
P-values are presented as noncorrected for multiple testing. Significant results are indicated in bold.