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. 2010 Oct 11;5(10):e13282. doi: 10.1371/journal.pone.0013282

Figure 2. Attenuation of intraerythrocytic growth rate in mutant Plasmodium falciparum clones.

Figure 2

(A) Categorization of piggyBac-transformed P. falciparum mutant clones as attenuated (with a reduced fold-change of >2 standard deviation (SD) from the mean of wild-type fold-change) and non-attenuated revealed attenuation of approximately 50% of the mutant clones. (B) Further sub-classification of the attenuated mutants as severely attenuated (with a reduced fold-change of >4 SD from the mean of WT fold-change) and moderately attenuated (with a reduced fold-change of 2>SD<4 from the mean of WT fold-change) showed severe attenuation of blood-stage growth in approximately 20% of the mutants.