Fig. 1. Cell cytotoxicity (cell viability assays) and infectivity of HPV16 pseudovirus (luciferase assays) in cells treated with gamma secretase inhibitors.
Human keratinocytes, HaCat cells, were treated with serial dilutions of (A) GSI-IX or (B) GSI-X 4 hours prior HPV16 pseudovirus exposure. Mouse C127 cells were treated with serial dilutions of (C) GSI-IX or (D) GSI-X 4 hours prior HPV16 pseudovirus exposure. Bioluminescent signals of cells with mock treatment (HPV16 pseudovirus only) were set as 100% respectively. N = 6.