Table 1. Ki values of 1, 2a, 2b, and 3 for rat nNOS, bovine eNOS and murine iNOS.
Kia(nM) | selectivity | ||||
---|---|---|---|---|---|
inhibitor | |||||
rat nNOS | eNOS | iNOS | n/e | n/i | |
1 | 7 | 19,000 | 5,800 | 2,700 | 830 |
2a | 50 | 58,000 | 10,000 | 1,200 | 200 |
2b | 220 | 59,000 | 13,200 | 270 | 60 |
3 | 110 | 58,000 | 21,800 | 530 | 200 |
The Ki values represent at least duplicate measurements with standard deviations of ±10%