Table 2. Ki values of 1, 2a, 2b, and 3 for rat nNOS and human nNOS.
Kia(nM) | selectivity | ||
---|---|---|---|
inhibitor | |||
rat nNOS | human nNOS | rat/human | |
1 | 7 | 50 | 7.1 |
2a | 50 | 290 | 5.8 |
2b | 220 | 1,800 | 8.2 |
3 | 110 | 490 | 4.5 |
The Ki values represent at least duplicate measurements with standard deviations of ±10%.