Table 2.

Hierarchical Linear Models of Evening Fatigue, Morning Fatigue, and Sleep Disturbance

Evening Fatigue	Coefficient (SE)
Variable	Unconditional Model	Final Model
Fixed Effects
Intercept	4.283 (0.127) e	4.322 (0.181) e
Timea (linear rate of change)	0.075 (0.013) e	0.075 (0.013) e
Time2 (quadratic rate of change)	−0.003 (0.0005) e	−0.003 (0.0005) e
Time invariant covariates
Intercept: Age		−0.044 (0.009) e
Gender		0.458 (0.214) c
Genotype		−0.786 (0.216) d
Linear:  Baseline evening fatigue × time		−0.028 (0.006) e
Quadratic:  Baseline evening fatigue × time2		0.002 (0.0002) e
Variance components
In intercept	3.714e	3.159 e
In linear rate	0.022e	0.023 e
In quadratic fit	0.00003e	0.00003 e
Goodness-of-fit deviance(parameters estimated)	11305.680 (10)	11246.199 (15)
Model comparison (χ2 [df])		59.48 (5) e
Morning Fatigue	Coefficient (SE)
Variable	Unconditional Model	Final Model
Fixed Effects
Intercept	2.431 (0.111) e	2.545 (0.121) e
Timea (linear rate of change)	0.035 (0.012) d	0.035 (0.012) d
Time2 (quadratic rate of change)	−0.002 (0.0005) e	−0.002 (0.0005) e
Time invariant covariates
Intercept: Age		−0.054 (0.009) e
Genotype		−0.311 (0.178) b
Linear:   Age × time		−0.004 (0.001) e
Baseline morning fatigue × time		−0.051 (0.006) e
Quadratic:  Age × time2		0.0002 (0.00004) e
Baseline morning fatigue × time2		0.002 (0.0002) e
Variance components
In intercept	2.780e	2.384 e
In linear rate	0.019e	0.020 e
In quadratic fit	0.00002e	0.00003 e
Goodness-of-fit deviance(parameters estimated)	10762.335 (10)	10700.277 (16)
Model comparison (χ2 [df])		62.06 (6) e
Sleep Disturbance	Coefficient (SE)
Variable	Unconditional Model	Final Model
Fixed Effects
Intercept	41.045 (1.114) e	43.481 (1.325) e
Timea (linear rate of change)	−0.144 (0.037) e	−0.146 (0.033) e
Time invariant covariates
Intercept: Age		−0.338 (0.092) d
Genotype		−6.760 (2.17) d
Linear:   Baseline sleep disturbance × time		−0.008 (0.002) e
Variance components
In intercept	271.521e	248.32 e
In linear rate	0.143e	0.086 e
Goodness-of-fit deviance(parameters estimated)	12550.001 (6)	12522.495 (9)
Model comparison (χ2 [df])		27.51 (3) e

^aTime was coded 0 at the time of the simulation visit

^bP = 0.08.

^cP < 0.05.

^dP ≤ 0.01.

^eP < 0.0001.