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. Author manuscript; available in PMC: 2011 Oct 15.
Published in final edited form as: Org Lett. 2010 Oct 15;12(20):4478–4481. doi: 10.1021/ol101655h

Table 1.

Analysis of the Reaction of 1 with MeOH under Various Conditions

graphic file with name nihms-237590-t0004.jpg
entry conditionsa timeb % yieldc
1 MeOH (20 molar equiv) 24 h NRd
2 MeOH (20 molar equiv), (i-Pr)2NEt (2
molar equiv)		 24 h NRd
3 MeOH (20 molar equiv), DBU (2 molar
equiv)		 45 min 75
4 MeOH (20 molar equiv), Cs2CO3 (2
molar equiv)		 45 min 77
a

Reactions were conducted using 70 μmol of 1 in MeOH.

b

Reactions were monitored by TLC.

c

Yields reported are of isolated and purified product.

d

No reaction was observed, and only 1 was observed by TLC.