Table 1A. Heterogeneous expression of CD19 in MCL patient samples.

The percentages of CD45+CD19− cells were calculated based on expression levels with IgG isotype control (not shown). CD3+ and CD34+ cells were separated from mononuclear cells of each sample as described in the Materials and Methods section. All CD45+CD19− xenograft tumors displayed the same light chain restriction patterns as the original patient cells. Intracellular stainings were performed to analyze light chain restriction patterns as described in Materials and Methods. CD45+CD19− xenograft tumors displayed the same light chain restriction patterns that match the original patient tumor cells.

Patient #	% of CD45+CD19− cells	Light chain restriction in patient samples	Light chain restriction in CD45+CD19− xenografts
Pt 1	8 %	Lambda	Lambda
Pt 2	10 %	Kappa	Kappa
Pt 3	9 %	Lambda	Lambda
Pt 4	3 %	Lambda	Lambda
Pt 5	15 %	Kappa	Kappa
Pt 6	11 %	Kappa	Kappa
Pt 7	10 %	Lambda	Lambda
Pt 8	7 %	Lambda	Lambda