Table 2B. Treatment of immunosuppressive antibodies to NOD/SCID mice does not influence engraftment of MCL tumor cells.
CD122 antibody (200 μg) was administrated by intraperitoneal injection on the day before transplantation. MCL tumor cells incubated with anti-CD19 or isotype control were injected into anti-CD122-treated NOD/SCID mice. Both populations formed MCL-like tumors in all mice tested.
Cells injected | Cell dose | # of mice tested | Total # of mice have tumors |
---|---|---|---|
MCL tumor cells (pt1, pt3) + anti-CD19 antibodies Injected into anti-CD122 treated NOD/SCID mice | 5×106 | 5 | 5/5 (100%) |
MCL tumor cells(pt1, pt3) + IgG antibodies Injected to anti-CD122-NOD/SCID mice | 5×106 | 2 | 2/2(100%) |