Table 4.
The effects of lycopene supplementation on histopathological changes.
| Parameters | Control group (n = 10) | HFD (n = 10) | HFD + 2 mg/kg lycopene (n = 9) | HFD + 4 mg/kg lycopene (n = 10) |
|---|---|---|---|---|
| Steatosis (0–4) | — | 1,30 + 0,48† | 0,6 ± 0,51* | 0,70 ± 0,48* |
| İnflammation (cells/mm2) | 2,11±1,07 | 12,45 ± 6,0† | 4,50 ± 2,1** | 4,95, ±3,81** |
| Necrosis (foci/mm2) | — | 1,15 ± 0,87† | 0,72 ± 0,24 | 0,57 ± 0,38 |
| Fibrosis (0–4) | — | 0,50 ± 0,52† | 0,60 ± 0,51 | 0,20 ± 0,42 |
| CYP 2E1 expression | 1,0 ± 0,0 | 2,60 ± 0,51† | 1,70 ± 0,48** | 1,20 ± 0,42** |
| α-SMA expression | — | 2,50 ± 0,52† | 1,80 ± 0,62* | 1,40, ±0,16** |
*P < .05: versus HFD group, **P < .01: versus HFD group; versus HFD group, †P < .01: versus control group.