Table 2.
Data of cases with HCM.
| Type | N. | W.g. at dg. | Assoc. ECAs/ other conditions | Heart failure | Arrh. | Ther. in utero | Outcome in utero—w.g. TP IUD Delivery |
Postnatal death |
Total death of cases continuing pregn. | Alive/age |
|---|---|---|---|---|---|---|---|---|---|---|
| “Idiop.” | 17 | 5 familial history | — | — | — | 1 lost 11 delivered at 31-38 w.g. |
1–38 d (met.dis) | 2/16 with known f-up = 125% | 14 alive at 2–14 yrs: 3 worsened—1 Tx at 2 m; 1 operated at 3 yrs for LVOT-mitral tissue obstruction; 1 needing betablockers; 5 unchanged (mild-moderate); 6 improved at 3 m–1 yr. |
|
| 12 no familial history | 1 prem. born at 28 w.g. died at 15 d. | |||||||||
|
| ||||||||||
| Secondary to ECA | 26 | 17–30 Median 22 | 16 renal, 3 CNS, 7 (skeletal anom., arthrogryposis, Thomas s., Noonan s.) |
3 (mild-moder.) | 8 TP, 6 IUD at 23–30 w.g., 12 delivered at 28–37 w.g. |
7 (1–35 d) | 13/18 = 72.2% | 5 alive, regressed | ||
|
| ||||||||||
| Secondary to maternal diabetes | 17 | 27–37 | 12 pregest., 5 gest. | 1 (mild) | 1 flutter | Dig.* | 17 delivered at 37–39 w.g. | 2 (2 d, 4 m) | 2/17 = 11.8% | 15 alive, normalized at 3–6 m |
|
| ||||||||||
| HCM total | 60 | 17–39 | 4 (6.7%) | 1 | 1 | 8 TP, 6 IUD, 1 lost, 45 delivered |
11/51 with known f-up = 21.6% | 17/51 with known f-up = 33.3% | 34 alive, 2 worsened, 6 unchanged, 26 improved/normalized |
|
Idiop.: idiopathic, n.: number, w.g.: weeks' gestation, dg.: diagnosis, ECAs: extracardiac anomalies, anom.: anomalies, CNS: central nervous system, s.: syndrome, arrh.: arrhythmias, SVT: supraventricular tachycardia, ther.: therapy, dig.: digoxin, TP: termination of pregnancy, IUD: intrauterine death, d: day, m: month, yr: year, s.: syndrome, met.dis.: metabolic disease, prem.: premature, gest.: gestational, pregest.: pregestational, moder.: moderate, f-up: follow-up, Tx: heart transplant, and LVOT: left ventricular outflow tract.