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. 2010 May 18;38(18):6234–6246. doi: 10.1093/nar/gkq376

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© The Author(s) 2010. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — IsomiRs that demonstrate existence of SNPs or post-transcriptional modifications. For each presented miRNA, its main isomiRs, responsible for at least 5% of all sequences in the tumor libraries, were retrieved. These were aligned using ClustalW (51) and the resulting alignment is visualized as position-specific scoring matrix using WebLogo (52). The sequenced isomiRs of each miRNA are compared to the human genome and the reference miRNA sequence from miRBase database. (A) hsa-miR-143, (B) hsa-miR-140-5p, (C) hsa-miR-100, (D) hsa-miR-150 and (E) hsa-miR-1274b.