Table 1.
Summary of DAVID GO analysis of nearest genes to FXR-binding regions
| Top GO Categories of nearest genes to peaks | |||
|---|---|---|---|
| PANTHER BIOLOGICAL PROCESS | Count | P–value | FDR |
| BP00019: Lipid, fatty acid and steroid metabolism | 58 | 5.48E-08 | 6.97265E-05 |
| BP00036: DNA repair | 86 | 2.46E-07 | 3.12E-04 |
| BP00143: Cation transport | 164 | 1.45E-06 | 1.84E-03 |
| BP00033: Pyrimidine metabolism | 26 | 3.54E-05 | 4.50E-02 |
| BP00141: Transport | 71 | 5.77E-05 | 7.33E-02 |
| BP00008: Tricarboxylic acid pathway | 17 | 1.35E-04 | 0.172142101 |
| BP00104: G-protein mediated signaling | 144 | 1.40E-04 | 0.17745439 |
| BP00286: Cell structure | 137 | 1.44E-04 | 0.182437201 |
| BP00071: Proteolysis | 198 | 2.22E-04 | 0.282634364 |
| BP00276: General vesicle transport | 49 | 3.36E-04 | 0.426752545 |
| BP00063: Protein modification | 115 | 3.66E-04 | 0.465131227 |
| BP00153: Complement-mediated immunity | 25 | 8.04E-04 | 1.017828781 |
| BP00076: Electron transport | 41 | 2.99E-03 | 3.743358089 |
| BP00014: Amino acid biosynthesis | 25 | 3.07E-03 | 3.837211045 |
| BP00013: Amino acid metabolism | 18 | 3.10E-03 | 3.877861993 |
| BP00044: mRNA transcription regulation | 336 | 3.66E-03 | 4.561346276 |
| BP00142: Ion transport | 87 | 7.08E-03 | 8.643459039 |
| BP00005: Glycolysis | 18 | 7.58E-03 | 9.221152371 |
| BP00103: Cell surface receptor mediated signal transduction | 86 | 8.51E-03 | 10.29998477 |
| BP00193: Developmental processes | 78 | 1.11E-02 | 13.186538 |
| BP00298: Glycogen metabolism | 18 | 1.92E-02 | 21.87988309 |
A total of 1038 genes for peaks located within 20 kb of a gene were used to group into enriched functionally important categories using PANTHER.