Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Comparison of DNA binding of purified wild-type and mutant SOX9 proteins to the Col2a1 enhancer harboring mutations in SOX9 binding Sites 1 and 2. (A) Wild-type and mutant Col2a1 probes for which the upper strand of the wild-type sequence is shown. Sites 1 and 2 correspond to 7-bp HMG-like binding sites. Mutated nucleotides in Sites 1 and 2 are indicated. (B) EMSA with wild-type and mutant probes using recombinant wild-type and dimerization mutant SOX9.
