Table 3.
A survey of alternative exon splicing events identified with MapSplice junctions
| Coverage | Alternative exon events |
Mutual Excl. | |||
|---|---|---|---|---|---|
| Sample | Skipped Exon | Alt. Start | Alt. End | ||
1 |
BAS | 6880 | 6700 | 7474 | 442 |
| BAS | 7365 | 7611 | 8005 | 454 | |
| SUM | 5574 | 5690 | 6359 | 353 | |
| SUM | 5491 | 5701 | 6451 | 337 | |
| LUM | 6523 | 7326 | 7777 | 387 | |
| LUM | 6321 | 6928 | 7625 | 355 | |
| MCF | 6776 | 6338 | 7350 | 472 | |
| MCF | 6352 | 6063 | 7083 | 444 | |
2 |
BAS | 2726 | 2144 | 2564 | 101 |
| BAS | 2941 | 2529 | 2689 | 111 | |
| SUM | 2271 | 2098 | 2347 | 103 | |
| SUM | 2277 | 2096 | 2359 | 95 | |
| LUM | 2599 | 2542 | 2574 | 95 | |
| LUM | 2333 | 2031 | 2387 | 86 | |
| MCF | 2949 | 2410 | 2778 | 129 | |
| MCF | 2669 | 2331 | 2588 | 109 | |
5 |
BAS | 651 | 476 | 614 | 26 |
| BAS | 718 | 522 | 641 | 23 | |
| SUM | 644 | 538 | 643 | 25 | |
| SUM | 623 | 528 | 656 | 25 | |
| LUM | 618 | 538 | 582 | 22 | |
| LUM | 503 | 386 | 528 | 21 | |
| MCF | 815 | 686 | 780 | 30 | |
| MCF | 757 | 656 | 735 | 22 | |
Four different types of alternative splicing events involving at least two splice junctions were identified in each sample. They are exon skipping events, alternative 3′-end, alternative 5′ start and mutually exclusive exons. Alternative splicing events were examined at different expression levels, only junctions with coverage larger than the given threshold (1, 2, 5) were considered. In general, there are about 35% exon skipping events, 30% alternative 5′ start events, 34% alternative 3′-end events and 1.3% mutually exclusive exon events.


