Table 3.
Divergence in the binding site residues of phosphodiesterases.
| PDE7A[a] | PDE2A | PDE3B | PDE4D | PDE5A | PDE9A | PDE10A |
|---|---|---|---|---|---|---|
| Tyr211 | Tyr | Tyr | Tyr | Tyr | Phe | Tyr |
| Ile323 | Leu | Leu | Met | Leu | Met | Leu |
| Ile363 | Leu | Ile | Leu | Leu | Ile | Leu |
| Asn365 | Asp | Gly | Asn | Ala | Asn | Ser |
| Pro366 | Gln | Pro | Pro | Ile | Glu | Val |
| Ser373 | Thr | His | Tyr | Gln | Ala | Thr |
| Ser377 | Ala | Thr | Thr | Ala | Val | Ala |
| Val380 | Ile | Ile | Ile | Val | Leu | Ile |
| Phe384 | Phe | Phe | Phe | Phe | Tyr | Phe |
| Leu401 | Met | Phe | Met | – | Phe | Met |
| Ile412 | Leu | Leu | Ser | Met | Ala | Gly |
| Leu420 | Ile | Ile | Ile | Ile | Val | Val |
[a]
PDE7A1 residues with nonconservative changes are shown in bold.