Figure 4.

Overexpression of hNEDL1 induced neuron degeneration in lumbar spinal cord and skeletal muscle atrophy. Bodian-stained section of frontal cortex, hippocampus, striatum (bar = 50 μm), and lumbar spinal cord (bar = 20 μm). Degenerated motor neurons and decreased axon are observed in the lumbar spinal cord in the hNEDL1-Tg mouse. The numbers of motor neuron in the total motor neuron and in the degenerated motor neuron from wild-type mice (white bar: n = 12) and hNEDL1-Tg mice (black bar: n = 11) from the age of six to fifteen months were shown. Data are mean ± SEM (*P < .05).