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Comparison of BL and B-LCL highlighting the protein expression pattern of immune components that affects their abilities to stimulate CD4+ T cells. BL cells normally express EBNA1, but not EBNA2 and LMP1. When compared to B-LCL, BL cells express higher levels c-myc, HLA-DO and BLAIM and lower levels of costimulatory molecules (CD80/86) that differentially regulate Ag processing and presentation, resulting in poor CD4+ T cell recognition of BL.
