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. Author manuscript; available in PMC: 2010 Oct 12.
Published in final edited form as: J Neurochem. 2009 Aug 19;111(3):696–702. doi: 10.1111/j.1471-4159.2009.06350.x

Fig. 2.

Fig. 2

No neurodegeneration in the SNpc and LC of TKO mice. (a–d) Normal immunoreactivity and morphology of SN neurons in TKO mice at the age of 24 months. Scale bars: 100 μm. (e) Similar numbers of TH-immunoreactive neurons are present in the SNpc of TKO mice and wild-type controls at the ages of 3 months (+/+: 12720 ± 992, n = 4; −/−: 11080 ± 740, n = 4; p > 0.05), 16 months (+/+: 11460 ± 1735, n = 4; −/−: 11880 ± 605, n = 4; p > 0.05), and 24 months (+/+: 11008 ± 736, n = 5; −/−: 10440 ± 396, n = 4; p > 0.05). All data are expressed as mean ± SEM. (f–i) Normal immunoreactivity and morphology of TH+ neurons in the LC of TKO mice at the age of 24 months. Scale bars: 100 μm. (j) Similar numbers of TH-immunoreactive neurons are present in the LC of TKO mice and wild-type controls at the ages of 3 months (+/+: 308 ± 16, n = 3; −/−: 298 ± 13, n = 4; p > 0.05), 16 months (+/+: 284 ± 38, n = 3; −/−: 236 ± 17, n = 4; p > 0.05), and 24 months (+/+: 231 ± 21, n = 4; −/−: 265 ± 16, n = 4; p > 0.05). All data are expressed as mean ± SEM.