TABLE 5.
pol and UL97 changes from baseline after drug exposure in vivo or in vitro with undetermined significancea
| Gene | Codon no. | Amino acid(s)/mutation |
Reference | |
|---|---|---|---|---|
| Wild type | Mutant | |||
| UL97 | 590 | AACRALENGKL | Del 11b | 210 |
| 590 | AACRALENGKLTHC | Del 14 | 29 | |
| 592 | C | F | 210 | |
| 594-595 | AL | Del 2 | 171 | |
| 596 | E | Del | 24 | |
| 599 | K | E | 24 | |
| 599 | K | M | 210 | |
| 600 | LT | Del 2 | 104 | |
| 601 | T | M | 8 | |
| pol | 412 | F | S | 132 |
| 419 | T | M | 155 | |
| 500 | K | N | 82 | |
| 501 | L | F | 74 | |
| 552 | T | N | 82 | |
| 578 | Q | H | 155 | |
| 585 | S | A | 82 | |
| 757 | N | K | 82 | |
| 773 | L | V | 155 | |
| 802 | L | R | 82 | |
| 802 | L | V | 82 | |
| 829 | P | S | 82 | |
| 841 | G | S | 24 | |
| 879 | D | G | 82 | |
| 926 | L | V | 82 | |
| 957 | L | F | 82 | |
This table contains examples of sequence changes from baseline observed after exposure to antiviral drugs but not confirmed by marker transfer.
Deletion starting at the designated codon and continuing through the number of codons shown.