TABLE 3.

In vitro activities of antifungal agents against selected melanized fungi^a

Species	Activityb
	AmB	Itra	Vori	Posa	Isavu	Ravu	Keto	Terb	5-FC	Casp	Mica	Anid
Alternaria spp.	+	++	+	++	+			+	−	+		+
Aureobasidium pullulans	+	++	++
Bipolaris spp.	+	++	++	++	+	+		+		+		+
Chaetomium spp.	+	++	++			++	+		−
Cladosporium spp.	+	++	++					++	+		+
Cladophialophora bantiana	++	++	++	++			+	+	+	+	++	+
Curvularia spp.	+	++	++	++	+	+		+		+
Exophiala spp.	+	++	++	++	+	+		+	+	+		+
Exophiala dermatitidis	++	++	++	++		+	+	+	+		+	+
Exserohilum spp.	++	++	++			+		+
Fonsecaea pedrosoi	++	++	++			+	++	++	+	+	+	+
Lasiodiplodia theobromae								+
Madurella mycetomatis	+	++	++				++	+	−			+
Ochroconis gallopava	+	++	+
Phialemonium spp.	+	+	+
Phialophora spp.	+	++		++		+		+	+	+		+
Rhinocladiella spp.	+	++	++			+			+
Rhinocladiella mackenziei	+	+	+	+	+				+	−		−
Scedosporium/Pseudallescheria spp.	−	+	++	+
Scedosporium prolificans	−	−	−	−				−		−	−	−
Scopulariopsis brumptii	−	−		−								−
Veronaea botryosa		+	+
Wallemia sebi	+	+	+	+				+	−		+

^aAdapted from reference 625 with permission of Expert Reviews Ltd.

^bAbbreviations: AmB, amphotericin B; 5-FC, flucytosine; Keto, ketoconazole; Itra, itraconazole; Vori, voriconazole; Posa, posaconazole; Ravu, ravuconazole; Casp, caspofungin; Mica, micafungin; Anid, anidulafungin; Terb, terbinafine; Isavu, isavuconazole. ++, good activity suggested based on consistently low MICs and testing against at least five isolates of a particular genus or species; +, potential/marginal activity suggested based on inconsistent MICs or very few isolates of a particular genus or species; −, no significant activity suggested based on consistently high MICs. The results do not represent formally defined CLSI breakpoints.