MBL mutations compared in 277 patients with pulmonary tuberculosis (TB) and 288 household contacts; HYA/HYA subjects |
|
were protected against tuberculosis (OR, 0.09; P < 1 × 10−6); LYB/LYD subjects were susceptible to disease (OR, 49; |
|
P < 1 × 10−6) |
52 |
Relationships between the susceptibility to TB exon 1 mutations and MBL levels in Turkish children; 27 children with |
|
pulmonary TB and 17 with extrapulmonary TB compared to 99 age-matched healthy controls; AB genotype (low MBL |
|
level) significantly lower in patients (9.1%) than in controls (27.3%) (P < 0.011); Median MBL levels significantly lower in |
|
the control group than in cases |
73 |
Study of MBL levels and MBL2 gene polymorphisms in HIV-1-infected patients without TB (HIV+ TB−) (n = 151) and with |
|
TB (HIV+ TB+) (n = 109), HIV− TB+ patients (n = 148), and healthy controls (n = 146); MBL levels significantly higher |
|
among HIV− TB+ and HIV+ TB+ patients than controls and HIV+ TB− patients (P < 0.05); increased frequency of O/O |
|
genotype and YY genotype among HIV− TB+ patients than controls; HIV+ TB+ patients had significantly increased |
|
frequency of YA/YA diplotype (high MBL levels) compared to controls (P = 0.03); HIV+ TB+ patients had significantly |
|
decreased frequency of medium MBL expression diplotypes (XA/XA and YA/YO) compared to HIV+ TB− patients and |
|
healthy controls; YA/YA diplotype (high MBL) may predispose HIV+ patients to TB, while O/O genotype (low MBL) may |
|
predispose to TB in HIV− individuals; medium MBL expression diplotypes may protect against TB in HIV− patients |
2 |
Six MBL SNPs (A/B, A/C, A/D, H/L, Y/X, and P/Q) studied in 152 Chinese males with pulmonary TB vs 293 healthy |
|
controls; none of the variants individually contributed to risk of TB, although there was a slightly increased risk with XB |
|
(low MBL) haplotype |
258 |
MBL-2 structural and promoter polymorphisms in HIV infection and TB in a white Spanish population; 615 HIV+ with and |
|
without TB, 127 HIV− TB+ patients, 142 TB household contacts, and 344 controls; frequency of low producer or |
|
nonproducer mbl-2 genotypes lower in HIV patients than controls; HIV− TB+ patients had lower frequencies of low |
|
producer or nonproducer alleles and genotypes than HIV+ TB− patients and controls; positive correlation between |
|
incidence of TB and frequency of nonproducer mbl-2 alleles in Western Europe; MBL deficiency associated with lower risk |
|
of TB in HIV patients |
148 |
MBL B allele frequency lower in controls than TB cases among African-Americans (P < 0.01) but no differences found |
|
between cases and controls of white and Hispanic ethnicity |
112 |
Study of MBL alleles in 109 TB+ (and HIV-uninfected) patients living in Denmark and 250 white control subjects; low- |
|
expressing MBL genotype more frequent in controls than in white patients; similar trend in patients of other ethnic origin; |
|
heterozygosity for MBL variant alleles (low serum MBL) associated with protection against TB |
413 |
No significant difference in frequency of MBL variant alleles in Turkish population with or without TB |
334 |
Study of role of MBL in HIV and TB in Tanzania; HIV+ TB+ patients (n = 150) vs HIV− TB+ patients (n = 94) vs HIV−
|
|
TB− controls (n = 113); HIV− TB+ patients had significantly higher MBL levels than controls, HIV+ TB+, and HIV+
|
|
TB− patients; low MBL associated with HIV risk; high MBL associated with TB risk |
154 |
MBL alleles and TB in South African population; MBL B allele found in 22 of 79 (28%) of TB-negative controls compared |
|
with 12 of 91 (13%) of patients with pulmonary TB (P < 0.017) and 5 of 64 (8%) of patients with TB meningitis |
|
(P < 0.002); significantly lower serum MBL in TB-negative controls than in successfully treated |
|
TB patients (P < 0.004) |
190 |
Correlation between B and C alleles (prevalence in sub-Saharan Africans, 29%) and TB infection; areas with high prevalence |
|
of variant alleles (low MBL) have higher incidence of TB; high incidence of TB may select for low-MBL-expressing alleles |
305 |
No correlation between variant MBL alleles and TB in West African population |
25 |