TABLE 2.
Postimmunization serum antibody titers of chinchillas immunized intraperitoneally or intranasally with rAd HMW2 or rAd Hia
Adenovirus vector | Routea | No. of animals | ELISA titersb |
---|---|---|---|
rAd HMW2 | IP | 4 | 200, 800, 1,600, 3,200 |
rAd HMW2 | IN | 6 | <100, <100, <100, <100, 100, 100 |
rAd Hia | IP | 4 | 800, 3,200, 3,200, 3,200 |
rAd Hia | IN | 6 | 400, 400, 400, 800, 800, 1,600 |
IP, intraperitoneal administration with 108 PFU of the indicated recombinant vaccine; IN, intranasal administration with 107 to 109 PFU of the indicated recombinant vaccine.
Titers 1 month (intraperitoneal) or 2 months (intranasal) postimmunization; all samples were run in duplicate.