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Polyfunctional CD8+ T cell responses to HHV-8 peptide families. CD14− PBMC from healthy HLA A*0201-positive HHV-8-seropositive donors were stimulated for 1 week with autologous mature DC loaded with peptide. Peptide families are shown for LANA-1 17 (A), K12 7 (B), gB 44 (C), and K8.1 21 (D). Responses were measured by polychromatic flow cytometry, and net response values were averaged for three donors (mean + SE). Diagrams were generated using SPICE.
