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. 2010 Aug 4;17(10):1517–1523. doi: 10.1128/CVI.00108-10

FIG. 4.

FIG. 4.

Intravenous immunoglobulin (IVIG) can enhance the EV71 infection on THP-1 cells at subneutralization doses. THP-1 cells were infected with EV71 4643 stain at an MOI of 10 for 24 h alone or in the presence of various doses of IVIG. (A) The EV71 infection was detected by flow cytometry at 24 h postinfection. (B) The dose range of enhancement of EV71 infection on THP-1 cells by IVIG. (C) The virus titer was determined at 24 h postinfection by plaque assay. The neutralization titer of IVIG used with EV71 is 128. EV71 virus replication in THP-1 cells was enhanced at 500- and 1,000-μg/ml concentrations of IVIG.