FIG. 3.

BCG-induced PPD-specific T-cell responses. To investigate T-cell functions specific for PPD in groups 1, 4, and 5, an IFN-γ ELISPOT assay was performed at weeks zero, 6, and 11 after BCG vaccination. Error bars represent standard deviations. Asterisks indicate that the mean numbers of IFN-γ SFCs were significantly different. **, P < 0.01, as determined by analysis of variance (ANOVA) followed by a posthoc Tukey-Kramer test. There was no difference in IFN-γ SFCs between the old and young guinea pigs vaccinated with BCG.