FIG. 4.

UPR components required for hypoxic preconditioning (HP). (A and B) Wild-type (N2) animals were exposed to hypoxia (HP) or normoxia (control) incubations for 4 h and then allowed to recover for 20 h prior to a 20-h hypoxic incubation. Survival was scored after another 24-h recovery. (C) Survival from HP in the wild type and UPR mutants. Net survival (survival of HP-treated animals − survival of control animals) is plotted for each genotype. Each bar represents the means ± standard deviations from a minimum of three independent trials with at least 30 animals/trial. *, P < 0.01, paired t test, HP versus control.