Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic representation of the mutual antagonism of the Src-Stat3 and p53-PTEN axes in the regulation of cellular invasion. Two opposing forces, constituted by the proinvasive oncogenes Src-Stat3 and the anti-invasive tumor suppressors p53-PTEN, antagonize each other, affecting cellular invasive phenotypes. The dominant force likely determines the level of caldesmon expression and thereby the formation of invasive podosomes/invadopodia.
