TABLE 3.

Metabolic characteristics of WT, Par-1a^−/−, and Par-1b^−/− animals^a

Animal typed	Insulin (ng/ml)	Glucagon (pg/ml)	Leptin (ng/ml)	Adiponectin (μg/ml)		Triglyceride (mg/dl)	Cholesterol (mg/dl)	NEFAc (μmol/liter)
				Male	Female
WT	0.65 ± 0.10	45.5 ± 11.7	3.68 ± 0.26	9.8 ± 0.66b	17.9 ± 1.7	74.9 ± 3.46	83.27 ± 2.4	1,303 ± 65.8
Par-1a−/−	0.61 ± 0.08	31 ± 4.33	3.64 ± 0.16	16.5 ± 1.6	18.4 ± 2.2	73.1 ± 3.77	74.95 ± 2.87	1,329 ± 107
Par-1b−/−	0.37 ± 0.04	34 ± 2.25	3.02 ± 0.16	11.4 ± 1.3	11.7 ± 0.84	62.2 ± 3.39	73.45 ± 2.81	1,149 ± 66.3

^aTwenty-week-old mice on a regular chow diet were fasted overnight (n ≥ 11 per genotype, all male unless otherwise indicated); serum values are expressed as the means ± SEM of measurements obtained.

^bMale mice had significantly lower adiponectin levels (P = 0.0003). Note that this gender difference is lost in both Par-1 mice.

^cNEFA, nonesterified fatty acids.

^dP values were determined by Student's t tests comparing Par-1 mice to the WT. P values for WT and Par-1a^−/− mice were the following: insulin, 0.74; glucagon, 0.27; leptin, 0.79; adiponectin (male), 0.0008; adiponectin (female), 0.87; triglyceride, 0.74; cholesterol, 0.03; NEFA, 0.84. Values for adiponectin (male) and cholesterol were significant. P values for Par-1b^−/− mice were the following: insulin, 0.04; glucagon, 0.39; leptin, 0.16; adiponectin (male), 0.28; adiponectin (female), 0.005; triglyceride, 0.013; cholesterol, 0.011; NEFA, 0.11. Values for adiponectin (female), triglyceride, and cholesterol were significant.