TABLE 5.
Characteristics of febrile episodes with invasive fungal infections (IFI) and/or positive LightCycler SeptiFast test (SF) results for fungia
| IFI (EORTC-MSG criteria) | SF result | Persistent fever (>3 days) | Gastrointestinal tract mucositis and Candida colonization | Serological marker (GM, Mn, anti-Mn)b | CT finding consistent with IFI | Ongoing antifungal therapyc |
|---|---|---|---|---|---|---|
| Probable aspergillosis | - | + | − | Pos GMn in BALd | + (lungs) | + |
| Probable aspergillosis | - | + | − | Pos GMn in BALd | + (lungs) | + |
| Possible aspergillosis | A. fumigatus | − | − | Neg | + (lungs) | + |
| Possible candidiasis | C. albicans/C. parapsilosis | + | + | Pos anti-Mnd | + (liver, spleen) | − |
| Possible candidiasis | C. albicans | + | + | Pos anti-Mnd | + (liver, lungs) | + (empirical) |
| Possible candidiasis | C. tropicalis | + | + | Neg | + (spleen) | + (empirical) |
| Possible IFI | C. albicans | + | − | Neg | + (lungs) | + (empirical) |
| None | A. fumigatus | + | − | Neg | −e | − |
| None | C. albicans | − | + | Neg | − | − |
| None | C. tropicalis | + | + | Neg | − | + (prophylactic) |
| None | C. tropicalis | − | − | Neg | −e | − |
a
+, condition present; −, condition absent.
b
GMn, galactomannan; Mn, mannan; anti-Mn, anti-mannan antibodies; BAL, bronchoalveolar lavage fluid; Pos, positive; Neg, negative.
c
Values represent those seen at the time of a positive SF result or of an IFI diagnosis (EORTC-MSG criteria) when the SF result was negative.
d
Positive galactomannan, index ≥ 0.5; positive anti-mannan, ≥10 arbitrary units/ml.
e
Computed tomography (CT) not done.