TABLE 1.
Summary of clinical and virological measures
| Characteristic | Value for indicated mouse straina |
||
|---|---|---|---|
| 129 | IFNAR1−/− | STAT1−/− | |
| Time of maximum weight loss (dpi) | 4 | 4 | 9 |
| Maximum wt loss (% of starting wt) | 14-16 | 14-16 | >20 |
| Peak viral titer (PFU/g) | 2.6-3.8 × 107 | 3-7.2 × 107 | 7.6 × 107-3.4 × 108 |
| Viral RNA level at 2 dpi | 6.4-16 × 104 | 1.4-2.8 × 105 | 8.9-23 × 104 |
| Viral RNA level at 5 dpi | 1.2-20 × 102 | 3.7-25 × 102 | 3.1-4.4 × 104 |
| Viral RNA level at 9 dpi | 1.0-7.5 | 5.2-84 | 5.5-9.5 × 103 |
| Alveolar protein deposition at 9 dpi | No | No | Yes |
| Endpoint | Recovery | Recovery | Death |
a
The ranges of viral RNA levels are shown on an arbitrary scale as determined by quantitative RT-PCR results determined using probes for the SARS nucleoprotein gene (39). Three animals were used per set of conditions and time point.