FIG. 4.

Comparison of orthopoxvirus A56 genes. The protein sequences of vaccinia virus (VACV-WR) A56 and the homologs in variola virus (VARV-Bangladesh), monkeypox virus (MPXV-Zaire), and ectromelia virus (ECTV-Moscow) were downloaded from poxvirus.org and aligned using BLAST. Shaded residues indicate identical amino acids to vaccinia virus, and dashes represent missing amino acids. Conserved cysteines in the ectodomain are indicated in bold and with an arrow. The putative transmembrane domain is marked with the black line above the residues.